Steroid role in body

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system. [56] Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.

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Anabolic steroids attract young people and adults, who take these drugs to enhance athletic performance and improve their body image. Even though they may take these steroids with good intentions, they may not understand that the drugs are potentially harmful. These problems include aggressive behavior, liver disease, and increased risk of heart disease and certain cancers. Anabolic steroids also can cause permanent undesirable changes in sex characteristics, such as breast growth in men and increased facial hair and deepened voice in women. Among youth who have not attained their natural height, anabolic steroids can stunt their growth. Anabolic steroids should never be taken except while under a doctor's care.

Steroid role in body

steroid role in body

Anabolic steroids attract young people and adults, who take these drugs to enhance athletic performance and improve their body image. Even though they may take these steroids with good intentions, they may not understand that the drugs are potentially harmful. These problems include aggressive behavior, liver disease, and increased risk of heart disease and certain cancers. Anabolic steroids also can cause permanent undesirable changes in sex characteristics, such as breast growth in men and increased facial hair and deepened voice in women. Among youth who have not attained their natural height, anabolic steroids can stunt their growth. Anabolic steroids should never be taken except while under a doctor's care.

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