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Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development. There is about a 20%–35% risk for congenital defects in infants exposed to the drug in utero , and about 30%–60% of children exposed to isotretinoin prenatally have been reported to show neurocognitive impairment. Because of this, there are strict controls on prescribing isotretinoin to women who may become pregrant and women who become pregnant while taking isotretinoin are strongly advised to terminate their pregnancies.

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