A subset of patients with ALD will develop severe AH, which has a substantially worse short-term prognosis (37). AH also represents a spectrum of disease, ranging from mild injury to severe, life-threatening injury, and often presents acutely against a background of chronic liver disease (38,39). The true prevalence is unknown, but histological studies of patients with ALD suggest that AH may be present in as many as 10–35% of hospitalized alcoholic patients (40–42). Typically, symptomatic patients present with advanced liver disease, with concomitant cirrhosis in more than 50% of the patients, and superimposed acute decompensation. However, even patients with a relatively mild presentation are at high risk of progressive liver injury, with cirrhosis developing in up to 50% of the patients (43,44). The likelihood that AH will progress to permanent damage is increased among those who continue to abuse alcohol. Abstinence from alcohol in one small series did not guarantee complete recovery. Only 27% of the abstaining patients had histological normalization, whereas 18% progressed to cirrhosis, and the remaining patients had persistent AH when followed for up to 18 months (45).
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.