Of the possible side effects of Finasteride, the most severe revolve around women and pregnancy. Women who are pregnant or who may become pregnant must avoid contact with this compound at all cost. Men who use Finasteride should ensure their female counterparts do not come into contact with the compound. Finasteride can absorb through the skin, and even at a minimal amount this can cause significant damage to a male fetus. Data has also shown that Finasteride may be present in semen; the rate of absorption is unknown, but we do know that some is passed during intercourse. Men who use Finasteride will necessarily need to use condoms or avoid all sexual activity with women who may become pregnant. Failure to abide by this rule may lead to severe damage to the unborn child.
Pentoxifylline has been evaluated in patients with ASH for its antioxidant and anti-TNF properties. When compared to placebo, patients with severe AH (DF ⩾32) treated with pentoxifylline exhibited a higher 6-month survival. This survival benefit was not accompanied by significant changes in liver function but related to a marked reduction in the incidence of hepatorenal syndrome  . One subsequent randomized controlled trial in patients with cirrhosis related or not with ALD also supported the preventive effect of pentoxifylline on hepatorenal syndrome  . However, a sensitivity analysis restricted to the subgroup of patients with severe AH (DF ⩾32), failed to show a significant difference in survival between the pentoxifylline and placebo treated patients.