Oxandrolone appears to offer less hepatic stress than other c-17 alpha alkylated steroids. The manufacturer identifies oxandrolone as a steroid that is not extensively metabolized by the liver like other 17-alpha alkylated orals, which may be a factor in its reduced hepatotoxicity. This is evidenced by the fact that more than a third of the compound is still intact when excreted in the urine. 405 Another study comparing the effects of oxandrolone to other alkylated agents including methyltestosterone, norethandrolone, fluoxymesterone, and methandriol demonstrated that oxandrolone causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention of the agents tested. 406 20 mg of oxandrolone produced 72% less BSP retention than an equal dosage of fluoxymesterone,which is a considerable difference being that they are both 17-alpha alkylated.
The oral bioavailability of oxandrolone is 97%.  Its plasma protein binding is 94 to 97%.  The drug is metabolized primarily by the kidneys and to a lesser extent by the liver .   Oxandrolone is the only AAS that is not primarily or extensively metabolized by the liver, and this is thought to be related to its diminished hepatotoxicity relative to other AAS.   Its elimination half-life is reported as to hours but is extended to hours in the elderly.   Approximately 28% of an oral dose of oxandrolone is eliminated unchanged in the urine and 3% is excreted in the feces . 
Metandienone is the generic name of the drug and its INN , while methandienone is its BAN and métandiénone is its DCF .     It is also referred to as methandrostenolone and as dehydromethyltestosterone .      The former synonym should not be confused with methylandrostenolone , which is another name for a different AAS known as metenolone .