Metabolic/Endocrine: Decreased glucose tolerance (see PRECAUTIONS ), increased serum levels of low-density lipoproteins and decreased levels of high-density lipoproteins (see PRECAUTIONS , Laboratory Tests ), increased creatine and creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Reversible changes in liver function tests also occur, including increased Bromsulphalein (BSP) retention and increases in serum bilirubin , glutamic-oxaloacetic transaminase ( SGOT ), and alkaline phosphatase .
The formation of gallstones is probably one of the major causes of blockage in the bile ducts. This also results in the formation of stones of different sizes in the gallbladder that create a blockage in the common bile duct present at the liver base. In the event the duct continues to stay blocked waste matter starts getting collected in the bloodstream as well as the system of the bile duct. You may also develop a severe infection known as ascending cholangitis, if bacteria accumulates with the blockage and retreats into the liver. If the gallstone stops between the gallbladder and the common bile duct, an infection known as cholecystitis could result.
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