The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
Once more, an early study done on S-4 provided proof of full muscle regeneration in volunteers with degenerative disorders without the use of exercise and the minimum dosage of 3mg/kg/day. Changes can be seen anywhere from 1-2 weeks. This was the very first study classified S-4 as CLINICALLY SIGNIFICANT by improving skeletal muscle strength, lean body mass, and a reduction in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Unfortunately, there are always some side effects that arise when using Because S-4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing.
Before you can understand why Trenbolone works the way it does, you first need to understand that you have two types of fat, or adipose tissue, in your body. First, you have visceral adipose tissue, which surrounds your organs and has very little effect on your overall appearance. Second, you have subcutaneous adipose tissue, which rests just below the skin and has a tremendous impact on your appearance. As Trenbolone binds to androgen receptors (which it does very well), it inhibits lipid uptake. This means that your body cannot continue to add to its subcutaneous fat stores. As such, when you work out, you burn away the subcutaneous adipose tissue and obtain the “cut” appearance. This is why Tren is widely regarded as the best steroid to lose weight.